メカノトランスダクション

Delayed tooth movement in Runx2+/− mice associated with mTORC2 in stretch-induced bone formation.

Aonuma, T., Tamamura, N., Fukunaga, T., Sakai, Y., Takeshita, N., Shigemi, S., Yamashiro, T., Irma Thesleff, I., and Takano-Yamamoto, T. (2020).

Bone Reports, 100285.

L1CAM–ILK–YAP mechanotransduction drives proliferative activity of epithelial cells in middle ear cholesteatoma.

Yamamoto-Fukuda, T., Akiyama, N., & Kojima, H. (2020).

The American Journal of Pathology.

Differences between the root and horn cells of the human medial meniscus from the osteoarthritic knee in cellular characteristics and responses to mechanical stress.

Okazaki, Y., Furumatsu, T., Kamatsuki, Y., Nishida, K., Nasu, Y., Nakahara, R., Saito, T., and Ozaki, T. (2020).

Journal of Orthopaedic Science.

Mechanical Stress Regulates Epithelial Tissue Integrity and Stiffness through the FGFR/Erk2 Signaling Pathway during Embryogenesis.

Kinoshita, N., Hashimoto, Y., Yasue, N., Suzuki, M., Cristea, I. M., & Ueno, N. (2020).

Cell Reports, 30(11), 3875-3888.

Wnt/β-catenin signaling contributes to articular cartilage homeostasis through lubricin induction in the superficial zone.

Xuan, F., Yano, F., Mori, D., Chijimatsu, R., Maenohara, Y., Nakamoto, H., Mori, Y., Makii, Y., Oichi, T., Taketo, M. M, Hojo, H., Ohba, S., Chung, U. II., Tanaka, S., and Saito, T. (2019).

Arthritis Research & Therapy, 21(1), 1-11.

Stretch in Focus: 2D Inplane Cell Stretch Systems for Studies of Cardiac Mechano-Signaling.

Friedrich O, Merten A-L, Schneidereit D, Guo Y, Schürmann S and Martinac B. (2019)

Front. Bioeng. Biotechnol. 7:55. doi: 10.3389/fbioe.2019.00055

Impaired vascular smooth muscle cell force-generating capacity and phenotypic deregulation in Marfan Syndrome mice.

Nolasco, P., Fernandes, C. G., Ribeiro-Silva, J. C., Oliveira, P. V., Sacrini, M., de Brito, I. V., De Bessa, T. C., Pereira, L. V., Tanaka, L. Y., Alencar, A., and Laurindo, F. R. M. (2019).

Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 165587

Depletion of glycosphingolipids induces excessive response of chondrocytes under mechanical stress.

Matsubara, S., Onodera, T., Maeda, E., Momma, D., Matsuoka, M., Homan, K., Ohashi, T., and Iwasaki, N. (2019).

Journal of Biomechanics.

Responses of bladder smooth muscle to the stretch go through extracellular signal‐regulated kinase (ERK)/p90 ribosomal S6 protein kinase (p90RSK)/Nuclear factor‐κB (NF‐κB) Pathway.

Li, Y., He, M., Lin, W., Xiang, Z., Huang, J., Xu, P., Shi, Y., and Wang, H. (2019).

Neurourology and urodynamics.

Excessive mechanical loading promotes osteoarthritis through the gremlin-1–NF-κB pathway.

Chang, S. H., Mori, D., Kobayashi, H., Mori, Y., Nakamoto, H., Okada, K., Taniguchi, Y., Sugita S., Yano, F., Chung, U. II., Kim-Kaneyama, J. R., Yanagita, M., Economides, A., Canalis, E., Chen, D., Tanaka, S., and Saito, T. (2019).

Nature Communications, 10(1), 1442.

Yamada, M., Iwata, M., Warabi, E., Oishi, H., Lira, V. A., & Okutsu, M. (2019)

The FASEB Journal, fj-201900133R.

Two Diverse Hemodynamic Forces, a Mechanical Stretch and a High Wall Shear Stress, Determine Intracranial Aneurysm Formation.

Koseki, H., Miyata, H., Shimo, S., Ohno, N., Mifune, K., Shimano, K., Yamamoto, K., Nozaki, K., Kasuya, H., Narumiya, S., and Aoki, T. (2019).

Translational Stroke Research, 1-13.

Effects of mechanical forces on osteogenesis and osteoclastogenesis in human periodontal ligament fibroblasts: A systematic review of in vitro studies.

Li, M., Zhang, C., & Yang, Y. (2019).

Bone & Joint Research, 8(1), 19-31.

MT1‐MMP downregulation via the PI3K/Akt signaling pathway is required for the mechanical stretching‐inhibited invasion of bone‐marrow‐derived mesenchymal stem cells.

Fu, X., Halim, A., Tian, B., Luo, Q., & Song, G. (2019)

Journal of cellular physiology.

Mechanical regulation of oligodendrocyte morphology and maturation by the mechanosensor p130Cas.

Shimizu, T., Osanai, Y., Tanaka, K. F., Thai, T. Q., Abe, M., Natsume, R., Sakimura, K., and Ikenaka K. (2018).

Journal of Neurochemistry.

TRPV2 is required for mechanical nociception and the stretch-evoked response of primary sensory neurons.

Katanosaka, K., Takatsu, S., Mizumura, K., Naruse, K., & Katanosaka, Y. (2018)

Scientific reports, 8(1), 16782.

R‐spondin 2 promotes osteoblastic differentiation of immature human periodontal ligament cells through the Wnt/β‐catenin signaling pathway.

Arima, M., Hasegawa, D., Yoshida, S., Mitarai, H., Tomokiyo, A., Hamano, S., Sugii, H., Wada, N., and Maeda, H. (2018).

Journal of periodontal research.

Modeling human somite development and fibrodysplasia ossificans progressiva with induced pluripotent stem cells.

Nakajima, T., Shibata, M., Nishio, M., Nagata, S., Alev, C., Sakurai, H., Toguchida, J., and Ikeya, M. (2018)

Development, 145(16), dev165431.

Cyclic Stretching Exacerbates Tendinitis by Enhancing NLRP3 Inflammasome Activity via F-Actin Depolymerization.

Chen, Q., Zhou, J., Zhang, B., Chen, Z., Luo, Q., & Song, G. (2018)

Inflammation, 1-13.

Hypoxia Triggers SENP1 (Sentrin-Specific Protease 1) Modulation of KLF15 (Kruppel-Like Factor 15) and Transcriptional Regulation of Arg2 (Arginase 2) in Pulmonary Endothelium.

Pandey, D., Nomura, Y., Rossberg, M. C., Hori, D., Bhatta, A., Keceli, G., Leucker, T., Santhanam, L., Shimoda, L. A., Berkowitz,, D., and Romer, L.

Arteriosclerosis, thrombosis, and vascular biology, ATVBAHA-117.

MECHANOMEDICINE: applications of mechanobiology to medical sciences and next-generation medical technologies.

NARUSE, K. (2018).

Journal of Smooth Muscle Research, 54, 83-90.

Real-time imaging of mechanically and chemically induced ATP release in human lung fibroblasts.

Takahashi, K., Ito, S., Furuya, K., Asano, S., Sokabe, M., & Hasegawa, Y. (2017)

Respiratory Physiology & Neurobiology.

P2Y 6-deficiency increases micturition frequency and attenuates sustained contractility of the urinary bladder in mice.

Kira, S., Yoshiyama, M., Tsuchiya, S., Shigetomi, E., Miyamoto, T., Nakagomi, H., Shibata, K., Mochizuki, T., Takeda, M., Koizumi, S., (2017)

Scientific Reports, 7(1), 771.

Contribution of plasma membrane lipid domains to red blood cell (re) shaping.

Léonard, C., Conrard, L., Guthmann, M., Pollet, H., Carquin, M., Vermylen, C., Gailly, P., Van Der Smissen, P., Mingeot-Leclercq, M. P., Tyteca, D.

Scientific reports, 7(1), 4264.

Inhibitory effect of JAK inhibitor on mechanical stress-induced protease expression by human articular chondrocytes.

Machida, T., Nishida, K., Nasu, Y., Nakahara, R., Ozawa, M., Harada, R., Horita, M., Takeshita, A., Kaneda, D., Yoshida, A., Ozaki, T.

Inflammation Research, 1-11.

Real-time imaging of mechanically and chemically induced ATP release in human lung fibroblasts.

Takahashi, K., Ito, S., Furuya, K., Asano, S., Sokabe, M., & Hasegawa, Y. (2017)

Respiratory Physiology & Neurobiology.

Urothelial ATP exocytosis: regulation of bladder compliance in the urine storage phase.

Nakagomi, H., Yoshiyama, M., Mochizuki, T., Miyamoto, T., Komatsu, R., Imura, Y., … & Araki, I. (2016).

Scientific Reports, 6, 29761.

Bi-phasic activation of eNOS in response to uni-axial cyclic stretch is mediated by differential mechanisms in BAECs.

Takeda, H., Komori, K., Nishikimi, N., Nimura, Y., Sokabe, M., & Naruse, K. (2006).

Life sciences, 79(3), 233-239.

N-cadherin signals through Rac1 determine the localization of connexin 43 in cardiac myocytes.

Matsuda, T., Fujio, Y., Nariai, T., Ito, T., Yamane, M., Takatani, T., Takahashi, K., and Azuma, J. (2006).

Journal of molecular and cellular cardiology, 40(4), 495-502

Stretch-induced cell proliferation is mediated by FAK-MAPK pathway.

Wang, J. G., Miyazu, M., Xiang, P., Li, S. N., Sokabe, M., & Naruse, K. (2005).

Life sciences, 76(24), 2817-2825.

Mechanotransduction by integrin is essential for IL-6 secretion from endothelial cells in response to uniaxial continuous stretch.

Sasamoto, A., Nagino, M., Kobayashi, S., Naruse, K., Nimura, Y., & Sokabe, M. (2005).

American Journal of Physiology-Cell Physiology, 288(5), C1012-C1022.

Involvement of reactive oxygen species in cyclic stretch‐induced NF‐κB activation in human fibroblast cells.

Amma, H., Naruse, K., Ishiguro, N., & Sokabe, M. (2005).

British journal of pharmacology, 145(3), 364-373.

Characteristics of subepithelial fibroblasts as a mechano-sensor in the intestine: cell-shape-dependent ATP release and P2Y1 signaling.

Furuya, K., Sokabe, M., & Furuya, S. (2005).

Journal of cell science, 118(15), 3289-3304.

Activation of a mechanosensitive BK channel by membrane stress created with amphipaths.

Qi, Z., Chi, S., Su, X., Naruse, K., & Sokabe, M. (2005).

Molecular membrane biology, 22(6), 519-527.

Uni-axial cyclic stretch induces the activation of transcription factor nuclear factor κB in human fibroblast cells.

Inoh, H., Ishiguro, N., Sawazaki, S. I., Amma, H., Miyazu, M., Iwata, H., … & Naruse, K. (2002).

The FASEB Journal, 16(3), 405-407.

Molecular identification of a eukaryotic, stretch-activated nonselective cation channel.

Kanzaki, M., Nagasawa, M., Kojima, I., Sato, C., Naruse, K., Sokabe, M., & Iida, H. (1999).

Science, 285(5429), 882-886.

Orientation change of cardiocytes induced by cyclic stretch stimulation: time dependency and involvement of protein kinases.

Kada, K., Yasui, K., Naruse, K., Kamiya, K., Kodama, I., & Toyama, J. (1999).

Journal of molecular and cellular cardiology, 31(1), 247-259.

Activation of pp60 (src) is critical for stretch-induced orienting response in fibroblasts.

Sai, X., Naruse, K., & Sokabe, M. (1999).

Journal of cell science, 112(9), 1365-1373.

Up-regulation of COX2 expression by uni-axial cyclic stretch in human lung fibroblast cells.

Kato, T., Ishiguro, N., Iwata, H., Kojima, T., Ito, T., & Naruse, K (1998).

Biochemical and biophysical research communications, 244(3), 615-619.

Pp125^ F^ A^ K is required for stretch dependent morphological response of endothelial cells.

Naruse, K., Yamada, T., Sai, X. R., Hamaguchi, M., & Sokabe, M. (1998).

Oncogene, 17(4), 455-463.