Autofluorescence Quenching Illuminator

  • Efficient quenching with one simple step
  • Photo-bleached LEDs for improved signal-to-noise ratio
  • Effective for highly autofluorescent species


Fluorescent Staining

Autofluorescence Quenching


Eliminating autofluorescence reveals even weak signals

Autofluorescence, a cause of background noise for microscopy, is derived from lipofuscin, elastin fibers, vitamin A, and other naturally occurring molecules, and can often make fluorescence imaging of tissues difficult.


The TiYO™ quenches this autofluorescence by the use of photo-bleaching LEDs to increase the signal-to-noise ratio.


  • Just insert the sample and start. – No complicated procedures or special reagents required
  • High power LEDs and optimized exposure complete quenching in 30 minutes to a few hours

Only autofluorescence is quenched!

Unlike conventional quenching reagents, only autofluorescence signal is affected.

There is no reduction in the fluorescence from stains.


Evaporative cooling system

Powerful light irradiation combined with effective cooling prevents samples from overheating during photobleaching procedure.



ControlOnly power on/off *no other buttons/switches
Operation environment0 ~ +40°C、20 ~ 85%RH
Power SourceAC 100 ~ 240 V, 50/60 Hz
Max. power consumption310W
Size291 (W) × 210 (D) × 285 (H) mm
Weight10 kg
No. of samples per run

Up to 12 (microscope slides or TiYO™ chambers for free-floating sections/whole mount samples)


TiYO™ was jointly developed and commercialized using the technology invented by Associate Professor Yosuke Tsuneoka, Faculty of Medicine, Toho University (patent pending: JP-A 2021-008882).



Item No.: TiYO-TRAY: The dedicated TRAY for TiYO™ (Optional for the additional purchase) 


Item No.: TiYO-AD-WM: Dedicated Adaptors for Floating Tissue Sections or Whole-mount for TiYO™ (6 pcs. set, Optional purchase)


Note: The specifications and appearance of products on this page are subject to change without notice.

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